Effect of sildenafil citrate on prediabetic and diabetic albino rats treated with metformin

Authors

  • ahmed mohmed taha Department of physiology, faculty of medicine Port Said University,
  • Haredy Hassan Haredy Department of Pharmacology, Faculty of Medicine, Al-Azhar University, Assuit, Egypt.
  • Ahmed Ghareip Department of Physiology, Faculty of Medicine, Al-Azhar University, Assuit, Egypt.
  • Ahmed El sayed Nour el-deen Lecturer (Physiology Department, Faculty of Medicine, Al-Azhar University, EGYPT
  • Yasser M Ashour Department of Physiology, Egyptian Russian University

DOI:

https://doi.org/10.31878/ijcrpp.2021.51.02

Keywords:

Diabetes mellitus (DM), Sildenafil and Metformin

Abstract

Diabetes Miletus (DM) is a global epidemic disease. It is estimated that there are already 415 million adults aged 20–79 years diabetics worldwide. Sildenafil citrate is a phosphodiesterase type 5 (PDE5) inhibitor, which increases cyclic guanosine monophosphate (cGMP) and metformin (MET) is a biguanide used for the treatment of type 2 diabetes which increases peripheral insulin sensitivity.

Aim: This study aims to assess the effect of sildenafil citrate and metformin on lipid profile and glycemic control in diabetic and prediabetic albino rats.

Materials and methods: Adult male albino rats are used and divided into nine groups each group consists of 10 rats, diabetes is induced by feeding a high-fat diet (HFD) for an initial period of 2 weeks followed by a single intraperitoneal injection of (35 mg/kg) Streptozotocin. Prediabetes is induced by feeding (HFD) and glucose in water for a period of 2 weeks. Sildenafil was given in a dose of (5 &10 mg/kg/day orally for 4 weeks), metformin was given in a dose of (50 &100 mg/kg/day orally for 4 weeks) using oral gavages to normal healthy rats, diabetic and prediabetic rats. Blood samples were collected after 4 weeks of treatment in all experimental groups.

Results: Combined administration of sildenafil and metformin on diabetic rats improving hyperglycemia, oxidative stress, and hyperlipidemia induced by streptozotocin than the administration of metformin or sildenafil alone.

Conclusion: Sildenafil has beneficial effects against some diabetic complications. The present study showed that sildenafil with metformin has beneficial effects against diabetic complications.

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Published

2021-03-07

How to Cite

taha, ahmed mohmed, Haredy, H. H. ., Ghareip, A. ., el-deen, A. E. sayed N., & Ashour, Y. M. . (2021). Effect of sildenafil citrate on prediabetic and diabetic albino rats treated with metformin. International Journal of Current Research in Physiology and Pharmacology. https://doi.org/10.31878/ijcrpp.2021.51.02

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Section

Research Articles