@article{taha_Haredy_Ghareip_el-deen_Ashour_2021, title={Effect of sildenafil citrate on prediabetic and diabetic albino rats treated with metformin}, url={https://ijcrpp.com/index.php/ijcrpp/article/view/39}, DOI={10.31878/ijcrpp.2021.51.02}, abstractNote={<p>Diabetes Miletus (DM) is a global epidemic disease. It is estimated that there are already 415 million adults aged 20–79 years diabetics worldwide. Sildenafil citrate is a phosphodiesterase type 5 (PDE5) inhibitor, which increases cyclic guanosine monophosphate (cGMP) and metformin (MET) is a biguanide used for the treatment of type 2 diabetes which increases peripheral insulin sensitivity.</p> <p><strong>Aim</strong>: This study aims to assess the effect of sildenafil citrate and metformin on lipid profile and glycemic control in diabetic and prediabetic albino rats.</p> <p><strong>Materials and methods</strong>: Adult male albino rats are used and divided into nine groups each group consists of 10 rats, diabetes is induced by feeding a high-fat diet (HFD) for an initial period of 2 weeks followed by a single intraperitoneal injection of (35 mg/kg) Streptozotocin. Prediabetes is induced by feeding (HFD) and glucose in water for a period of 2 weeks. Sildenafil was given in a dose of (5 &10 mg/kg/day orally for 4 weeks), metformin was given in a dose of (50 &100 mg/kg/day orally for 4 weeks) using oral gavages to normal healthy rats, diabetic and prediabetic rats. Blood samples were collected after 4 weeks of treatment in all experimental groups.</p> <p><strong>Results</strong>: Combined administration of sildenafil and metformin on diabetic rats improving hyperglycemia, oxidative stress, and hyperlipidemia induced by streptozotocin than the administration of metformin or sildenafil alone.</p> <p><strong>Conclusion</strong>: Sildenafil has beneficial effects against some diabetic complications. The present study showed that sildenafil with metformin has beneficial effects against diabetic complications.</p>}, journal={International Journal of Current Research in Physiology and Pharmacology}, author={taha, ahmed mohmed and Haredy, Haredy Hassan and Ghareip, Ahmed and el-deen, Ahmed El sayed Nour and Ashour, Yasser M}, year={2021}, month={Mar.} }