SUPPLEMENTATION OF ZINC IN ACUTE AND CHRONIC HEAT STRESS ON ANTIOXIDANT CHANGES IN WISTAR ALBINO RATS
Introduction: Heat stress is a major health burden with potential health outcomes. Oxidative stress is metabolic dysfunction that carries oxidative damage of cells and tissues. Zinc is a co-factor against oxidative stress. Aim: The present study was done to evaluate the Supplementation of zinc in acute and chronic heat stress on antioxidant changes in Wistar albino rats. Methodology: 36 Wistar albino rats were selected for the study. They were divided into 2 groups. Group A was acutely and Group B was chronically heat-stressed rats and both were zinc pretreated. The Enzymatic and Non-enzyme activity in them were estimated.
Results: After acute and chronic heat stress, i) there was a significant increase (P <0.001) in lipid peroxidation activity. ii) Enzymatic and Non-enzymatic antioxidants were reduced (P < 0.001) iii) Rats pretreated with zinc showed a decrease (P< 0.001) in lipid peroxidation and increase (P < 0.001) in enzymatic antioxidants (P < 0.001) and Non-enzymatic antioxidants.
Key Words: antioxidants, heat stress, Wistar albino rats
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Copyright (c) 2020 antony madhuri bedadala; Dr Anthony David, DOCTOR
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