International Journal of Current Research in Physiology and Pharmacology 2023-12-10T06:58:53+00:00 Editor In Chief Open Journal Systems <p><strong>eISSN: 2523-6709, </strong><strong>pISSN: 2523-6695.</strong></p> <p style="text-align: left;">(Logos are embedded with links)</p> <hr /> <p style="text-align: left;"><a href=";refid=dcrecen" target="_blank" rel="noopener"><img src="" alt="" /></a> <a href=";publication=International+Journal+of+Clinical+and+Biomedical+Research&amp;publisher_str=Sumathi+Publications&amp;type=Journal+Article" target="_blank" rel="noopener"><img src="" alt="" /></a> <a title="IJCRPP" href=";as_sdt=0%2C5&amp;;oq=site" target="_blank" rel="noopener"><img src="" alt="" /></a> <a href=";qt=results_page" target="_blank" rel="noopener"><img src="" alt="" /></a> <a href="" target="_blank" rel="noopener"><img src="" alt="" /></a> <a href=";la=en" target="_blank" rel="noopener"><img src="" alt="" /></a></p> <hr /> <div class="flex-1 overflow-hidden"> <div class="react-scroll-to-bottom--css-ixafv-79elbk h-full"> <div class="react-scroll-to-bottom--css-ixafv-1n7m0yu"> <div class="flex flex-col pb-9 text-sm"> <div class="w-full text-token-text-primary" data-testid="conversation-turn-5"> <div class="px-4 py-2 justify-center text-base md:gap-6 m-auto"> <div class="flex flex-1 text-base mx-auto gap-3 md:px-5 lg:px-1 xl:px-5 md:max-w-3xl lg:max-w-[40rem] xl:max-w-[48rem] group final-completion"> <div class="relative flex w-full flex-col lg:w-[calc(100%-115px)] agent-turn"> <div class="flex-col gap-1 md:gap-3"> <div class="flex flex-grow flex-col max-w-full"> <div class="min-h-[20px] text-message flex flex-col items-start gap-3 whitespace-pre-wrap break-words [.text-message+&amp;]:mt-5 overflow-x-auto" data-message-author-role="assistant" data-message-id="465262a5-c138-4c1b-bbee-aac3b084ef7d"> <div class="markdown prose w-full break-words dark:prose-invert dark"> <p>The International Journal of Current Research in Physiology and Pharmacology (IJCRPP) serves as a platform for scientists in Health Sciences. This open-access, online and print journal is peer-reviewed and primarily focuses on Physiology, Pharmacology, and Clinical Medicine research and applications.</p> <p>Submission Guidelines:</p> <ul> <li>Articles must be in technical English, appropriate for scientific publication.</li> <li>Submissions should be original works, unpublished elsewhere, and not under consideration by other journals.</li> <li>All submissions undergo a peer-review process.</li> <li>Manuscript receipt is acknowledged via email.</li> <li>Review process aims to be completed within 3 weeks, with outcomes communicated to the corresponding author.</li> <li>Submissions are accepted electronically through the journal's website.</li> <li>The Editorial Board is committed to ensuring the journal's quality, and will index it in various bodies, with updates available on the website.</li> </ul> <p>Types of Manuscripts Accepted:</p> <ul> <li>Original research articles</li> <li>Reviews</li> <li>Case reports</li> <li>Short communications</li> <li>Letters to the editor</li> <li>Discussion papers</li> <li>Clinical Experience</li> <li>Clinicopathological correlation</li> <li>Book reviews</li> <li>"How to do it" articles on new methods or procedures</li> </ul> <p>Aims and Critical Objectives:</p> <ul> <li>To inspire new research ideas and encourage practical research application.</li> <li>Upholding the highest editorial integrity standards.</li> <li>Enhancing international health, healthcare, and health education through quality medical care, disease prevention, and research.</li> <li>Publishing significant, well-documented, peer-reviewed articles on basic medical sciences.</li> <li>Providing continuing education in basic science to physicians for better clinical decisions.</li> <li>Keeping doctors informed on various basic medical science aspects, including health education developments.</li> <li>Adhering to the highest ethical standards in medical journalism, ensuring the publication is timely, credible, and engaging.</li> </ul> <p>For further information, contact the Editor or the Journal Office via email.</p> <p>We eagerly await your submissions and hope you consider IJCRPP for your next manuscript.</p> <p>Kind Regards, <br />IJCRPP Editorial Team.</p> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> Postural changes in blood pressure and heart rate among healthy young adults in a Ghanaian university 2023-12-10T06:58:51+00:00 Perez Quartey Ernest Halm Obed Yeboah-Arhin <p><strong>Introduction: </strong>There are contradictory and inconsistent reports on the effects of different body postures on measured blood pressure and heart rate. This relationship has not been previously tested in the Ghanaian population.</p> <p><strong>Aim of the study: </strong>The overall aim of the study was to investigate the effects of different body positions on blood pressure and heart rate among Ghanaian healthy young adults.</p> <p><strong>Methods: </strong>Blood pressure and heart rate were measured subsequently in eight different positions on the left arm in the following non-randomized order: (i) sitting with arm flexed at the elbow and supported at the heart level on the chair, (ii) sitting with legs crossed, (iii) standing, (iv) supine, (v) right lateral recumbent, (vi) left lateral recumbent, (vii) prone, an (viii) bent with hands holding knees with face pointing to the ground. The repeated measures for ANOVA were used to compare the means in different positions. Statistically significance was pegged at p-value &lt; 0.05.</p> <p><strong>Results: </strong>The mean systolic and diastolic blood pressures were lowest in the right lateral recumbent position as compared to the other positions whiles the bent position recorded both the highest systolic and diastolic blood pressures and heart rate.</p> <p><strong>Conclusion: </strong>The highest mean blood pressure and heart rates are found in the bent position as compared to other body postures. The lowest mean systolic and diastolic blood pressures are found in the right lateral recumbent posture.</p> <p><strong>Keywords: </strong>Posture, blood pressure, heart rate, Ghanaian, Adults</p> 2023-12-10T00:00:00+00:00 Copyright (c) 2023 Perez Quartey, Ernest Halm, Obed Yeboah-Arhin To study different types of epileptic seizures and their treatment in a Superspeciality Hospital Jalandhar, Punjab, India 2023-12-10T06:58:50+00:00 Mashooq Ahmad Mir Abrar Bashir Malik Zulfkar Qadrie Mohd Altaf Dar <p><strong>Introduction: </strong>Epilepsy is a neurological disorder characterized by recurrent and unpredictable seizures, which are abnormal bursts of electrical activity in the brain. These seizures can vary in intensity and manifestation, causing a range of physical and cognitive effects. Epilepsy affects people of all ages and backgrounds, with over 65 million individuals’ worldwide living with the condition. Seizures in epilepsy can manifest in different ways, from convulsive jerking motions to momentary lapses in awareness. They can be triggered by various factors, including sleep deprivation, stress, flashing lights, or underlying brain conditions. Diagnosing epilepsy involves a comprehensive evaluation of a person's medical history, symptoms, and often electroencephalogram (EEG) tests to monitor brain activity. Treatment options for epilepsy aim to reduce the frequency and severity of seizures. This can include medication, which helps stabilize brain activity and prevent excessive electrical discharges. <strong>Objective: </strong>The objective of this study was to study different types of epileptic seizures and their treatment in a Superspeciality Hospital Jalandhar, Punjab, India. <strong>Methodology:</strong> This was a prospective, observational study investigating 90 patients with epileptic seizure in NASA AND HUB SUPERSPECIALITY HOSPITAL (NHS) located in Jalandhar Punjab for over a period of 4 months. This study revealed the treatment strategies used by physicians and correlation among treatment, control and complications of Epilepsy within the Indian context. This study eventually helped to develop person-centered care and facilitate public health agencies to invest appropriate resources in the management of Epilepsy in the health care system. <strong>Results:</strong> While studying about the gender wise distribution of patients, It was found that total number of patients at Nasa And Hub Superspeciality Hospital were 90, in which male patients were 60 accounting for 66.7% of study population, whereas the female patients were 30 accounting for 33.3% of total study population. <strong>Conclusion: </strong>The aim of the study was carried out to get the better awareness regarding epileptic seizures and to focus on the correct diagnosis for better treatment. The study focus on the most number of patients admitted at hospital with different types of seizures and the antiepileptic drugs to treat seizures. The study was done to differentiate between various groups of patients with epilepsy, of either sex or age.</p> <p><strong>Keywords: </strong>Epilepsy, Phenytoin, valproate.</p> 2023-12-10T00:00:00+00:00 Copyright (c) 2023 Mashooq Ahmad Mir, Abrar Bashir Malik, Zulfkar Qadrie, Mohd Altaf Dar A need of the hour: pharmacovigilance in healthcare setting – nothing less than safety 2023-12-10T06:58:53+00:00 Preeti Shanbhag Satish S Ramdas Bhat A R Shabaraya <p><strong>Introduction</strong>: Pharmacovigilance (PV) is crucial to identify, managing, and reporting adverse drug reactions (ADRs) in the healthcare sector. Young healthcare professionals (HCPs) play an essential role in the PV system. <strong>Objective</strong>: This study aimed to assess awareness, understand the causes of underreporting, and find solutions to encourage ADR reporting among young HCPs. <strong>Methods</strong>: This prevalidated, questionnaire-based, cross-sectional study aimed to evaluate the knowledge, attitude, perception, and strategies to improve PV reporting among 152 young HCP interns at a teaching hospital in India. The study was conducted in January 2023 and approved by the ethics committee. The responses were analysed using a Microsoft Excel worksheet<strong>. Results</strong> In a study of 152 interns, 97.3% agreed that pharmacovigilance (PV) may assist patients, but only 56% had experienced adverse drug reactions (ADRs) in practise. Only 40.5% chose email reporting, and 65.8% did not have a nearby ADR Monitoring Centre (AMC). More over half (53%) thought ADRs should only be reported to an AMC. Training sessions were underutilised, with only 28.6% attending PVPI training. The difficulty in identifying the causal substance, as well as a lack of incentives, were important reasons for underreporting. Continuing medical education/workshops were mentioned by 96% of young HCPs as a way to encourage reporting. <strong>Conclusion:</strong> According to the study, while young HCPs are aware of PV, there is a need for more training and incentives to enhance ADR reporting. Encouragement of National Pharmacovigilance Week and the availability of neighbouring AMCs could further aid raise PV awareness.</p> <p><strong data-id="_bold-18">Keywords:</strong> Adverse drug reactions (ADR), PVPI, AMC, CME</p> 2023-12-10T00:00:00+00:00 Copyright (c) 2023 Preeti Shanbhag, Satish S , Mr.Ramdas Bhat, A R Shabaraya Adverse Reactions Caused by Antiepileptic Medications in Real-World Medical Settings 2023-12-10T06:58:52+00:00 Mashooq Ahmad Mir Abrar Bashir Malik Zulfkar Qadrie Mohd Altaf Dar <p>Epilepsy is a relatively common condition characterized by a tendency for recurrent seizures, which is due to the disturbance of spread of electrical discharge of the cortical neurons. Up to 80% of people with epilepsy are able to control their condition with anti epileptic drugs (AEDs). The growing number of newly approved drugs for various illnesses coupled with the complex treatment options have contributed to the increased risk of adverse drug reactions (ADRs). AEDs have a narrow therapeutic index with wide spectrum of ADRs. 10-30% of epileptic patients discontinue their initially prescribed AEDs due to ADRs. These ADRs can be the cause of non-adherence and subjective distress. The newer generation AEDs have reduced adverse events, fewer drug interactions if any and thus improved safety. Comparison of adverse effects in patients taking AEDs with adverse events in control groups is helpful; however, data from controlled studies are often lacking for most AEDs. Because of these limitations, the clinician must adopt a preventative and early detection approach based on some general principles. This review outlines various adverse reactions related to the use of Anti-epileptic drugs.</p> <p><strong>Keywords</strong>: adverse reactions, antiepileptic drugs, carbamazepine, phenytoin</p> 2023-12-10T00:00:00+00:00 Copyright (c) 2023 Mashooq Ahmad Mir, Abrar Bashir Malik, Zulfkar Qadrie, Mohd Altaf Dar