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This open-access, online and print journal is peer-reviewed and primarily focuses on Physiology, Pharmacology, and Clinical Medicine research and applications.</p> <p>Submission Guidelines:</p> <ul> <li>Articles must be in technical English, appropriate for scientific publication.</li> <li>Submissions should be original works, unpublished elsewhere, and not under consideration by other journals.</li> <li>All submissions undergo a peer-review process.</li> <li>Manuscript receipt is acknowledged via email.</li> <li>Review process aims to be completed within 3 weeks, with outcomes communicated to the corresponding author.</li> <li>Submissions are accepted electronically through the journal's website.</li> <li>The Editorial Board is committed to ensuring the journal's quality, and will index it in various bodies, with updates available on the website.</li> </ul> <p>Types of Manuscripts Accepted:</p> <ul> <li>Original research articles</li> <li>Reviews</li> <li>Case reports</li> <li>Short communications</li> <li>Letters to the editor</li> <li>Discussion papers</li> <li>Clinical Experience</li> <li>Clinicopathological correlation</li> <li>Book reviews</li> <li>"How to do it" articles on new methods or procedures</li> </ul> <p>Aims and Critical Objectives:</p> <ul> <li>To inspire new research ideas and encourage practical research application.</li> <li>Upholding the highest editorial integrity standards.</li> <li>Enhancing international health, healthcare, and health education through quality medical care, disease prevention, and research.</li> <li>Publishing significant, well-documented, peer-reviewed articles on basic medical sciences.</li> <li>Providing continuing education in basic science to physicians for better clinical decisions.</li> <li>Keeping doctors informed on various basic medical science aspects, including health education developments.</li> <li>Adhering to the highest ethical standards in medical journalism, ensuring the publication is timely, credible, and engaging.</li> </ul> <p>For further information, contact the Editor or the Journal Office via email.</p> <p>We eagerly await your submissions and hope you consider IJCRPP for your next manuscript.</p> <p>Kind Regards, <br />IJCRPP Editorial Team.</p> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> Sumathi Publications en-US International Journal of Current Research in Physiology and Pharmacology 2523-6695 https://ijcrpp.com/index.php/ijcrpp/article/view/93 <p><strong>ABSTRACT</strong></p> <p><strong>Context</strong>: Given the high cost of treating diabetics with modern medicine in developing countries like Africa, traditional medicine has become an alternative widely practiced by them for their care. Hence the need to carry out a preclinical test in order to make improved traditional medicines available to diabetics in these countries at lower cost. It is in this context that we undertook to carry out scientific studies that could also promote traditional African medicine. <strong>General objective</strong>: To evaluate the hepatoprotective effects of aqueous extracts <em>of Annona senegalensis </em>(Annonaceae) (EAAs) and <em>Hallea ledermannii</em> (Rubiaceae) (EAHl), two plants known to be antidiabetic, in diabetic rats of the Wistar strain. <strong>Material and methods</strong>: The study of the effects of EAAs and EAHl on lipid profile parameters and markers of liver function in non-diabetic rats and in those made diabetic by induction of alloxan at a single dose of 75 mg/ kg of body weight (bw) was carried out after two (2), four (4), eight (8) and thirteen (13) weeks of treatment. Also, the study of the influence of the effects of these aqueous extracts on the liver of these animals was carried out after four (4) and thirteen (13) weeks of treatment. Furthermore, the histological analysis of the liver of the test rats was carried out after measuring the relative weight of this organ, on the 91st day of treatment. <strong>Results</strong>: After four (4) weeks of treatment, only the value of LDL cholesterol (LDL-c) in rats treated with EAAs (200 mg/kg bw) significantly decreased (p &lt; 0.05) compared to that of controls. untreated diabetics (1.27 ± 0.02 versus 1.18 ± 0.03 g/L). After 91 days of treatment, a significant increase in alkaline phosphatase and protein content was observed in diabetic rats treated with EAHl200 compared to the mean values ​​in untreated diabetic control rats respectively (137.5 ± 2. 50 against diabetic control values ​​93.50 ± 2.50) and (80 ± 3 g/L against diabetic control values ​​64 ± 4 g/L). At the same stage of treatment, the relative weight of the liver of all animals did not undergo significant variations (p &gt; 0.05) compared to that of non-diabetic controls. <strong>Conclusion</strong>: This study highlighted the hepato-protective properties of these extracts in diabetics.</p> <p><strong>Keywords</strong>: <em>Annona Senegalensis</em>, <em>Hallea ledermannii, </em>glibenclamide, hepato-protective, rat- diabetes.</p> Gooré Guy Charles Golé Nanti Dosso Kassim Dago Désiré Koudou Bi Semi Anthelme Néné Flavien Traoré Copyright (c) 2024 Gooré Guy Charles Golé Nanti, Dosso Kassim, Dago Désiré Koudou, Bi Semi Anthelme Néné, Flavien Traoré https://creativecommons.org/licenses/by-nc-sa/4.0 2024-07-17 2024-07-17 1 11