International Journal of Current Research in Physiology and Pharmacology en-US (Journal Office) (Support SP) Mon, 28 Nov 2022 00:00:00 +0000 OJS 60 Role of in-utero Neem leaf (Azadirachta indica) supplemented diet on some hematological parameters and glucose storage in offspring of Wistar rats. <p align="justify"><span dir="LTR"><em>Azadirachta indica</em></span><span dir="LTR"> (AI)</span><span dir="LTR"> Neem leaf is native of India which grows in most of tropical and subtropical countries. It tree has adaptability to a wide range of climatic, topographic and edaphic factors</span><span dir="LTR">. </span><span dir="LTR">This study explored the impact of AI supplementation during gestation on some haematological parameters and glucose storage in both offspring of Wistar rats</span><span dir="LTR">. </span><span dir="LTR">Eighteen</span><span dir="LTR"> p</span><span class="A3" dir="LTR">regnant female and 12 male Sprague-Dawley rats with a weight range of 140-180 grams were employed for this study and they were exposed to either a standard diet or AI supplementation (AIS). The pregnant rats </span><span dir="LTR">were exposed to AIS up to birth (gestational AI supplementation) which comprised of both treated males (TM) and treated females (TF). Control rats with control diet was administered in analogous comparatively and this comprised of control male (CM) and control females (CF)</span><span class="A3" dir="LTR">. During </span><span class="A3" dir="LTR">postnatal day 49, the rats were sacrificed and </span><span class="CharAttribute4" dir="LTR">blood sample was obtained for assay of </span><span dir="LTR">white blood cells (WBC), platelets (PLT), red blood cell counts (RBC), haemoglobin (Hb) and packed cell volume (PCV). Liver and gastrocnemius tissues were obtained for skeletal and hepatic glycogen assayed and intestinal and pancreatic α amylase and α glucosidase were determined from intestine and pancreatic tissues. </span><span dir="LTR">WBC, PLT, RBC, Hb, PCV, alpha amylase, hepatic and skeletal glycogen increased significantly (p&lt;0.05) in TM and TF with a remarkable decrease and increase in alpha glucosidase (p&lt;0.05) in TM and TF respectively compared with CM and CF. </span><span dir="LTR">It can be inferred from the present study that perinatal AI supplementation </span><span dir="LTR">provides a substantial justification to its use in folk medicine as a hematopoietic plant and the increased glucose storage observed may not be unconnected with its role as an hypoglycaemic agent though the effect were more marked in female offspring compared with the male counterparts.</span></p> Igbayilola Dimeji, Atoyebi Kayode, Aina OS, Aikpitanyi Ikponmwosa Copyright (c) 2022 Igbayilola Dimeji, AIKPITANYI, Aina, Atoyebi Kayode Mon, 28 Nov 2022 00:00:00 +0000 Reproductive Health of Women: Implications and attributes <p>Complete access to sexual and reproductive health is a fundamental human right. Women and girls all across the world, particularly those living in poverty, have little or no access to reproductive health and rights information and services. Discrimination, shame, restrictive laws and regulations, and long-held traditions are just a few of the barriers to sexual and reproductive health that exist. Despite evidence that these rights may affect not only individual women but also families, communities, and national economies, progress has been slow. Women's lifestyles have evolved throughout history. In the past, most women's lives were challenging. Many ladies were having unintended pregnancies. Childbirth used to be dangerous, and it often resulted in the mother's death. Because they didn't live long enough, most women didn't have to deal with menopause or old age in the past. Reproductive health is an important aspect of a person's entire development and well-being. It could be the result of a positive upbringing, which is critical during adolescence and sets the tone for excellent health throughout adulthood and beyond reproductive years for both men and women. A woman's reproductive life span does not begin at puberty and end at menopause, and a man's reproductive life span does not stop when he is no longer likely to bear children. It is present and vital at all stages of a person's development and maturation. Reproductive health needs may vary depending on one's age and stage of life. However, there is a long term effect over the course of one's life, and each stage has significant ramifications for one's future well-being.</p> Irfat Ara, Mudasir Maqbool, Imran Gani Copyright (c) 2022 Mudasir Maqbool, Irfat Ara, Imran Gani Mon, 28 Nov 2022 00:00:00 +0000 The Story of Polycystic Ovarian Syndrome: A Challenging Disorder with Numerous Consequences for Females of Reproductive Age <p>As the name implies, polycystic ovarian syndrome (PCOS) is a chronic hormonal disorder that mostly affects women of childbearing age. However, symptoms suggestive of androgen overproduction and ovarian dysfunction have been identified. It's a huge public health issue. Women with PCOS are more likely to have co-occurring diseases, as well as various other long-term metabolic and health issues. Prevalence has risen steadily during the last decade, and it's expected to continue rising. Many health care providers and individuals might avoid it if they shared more information. Everything from the initial diagnosis to pathogenesis to effects and treatment options is still up for debate. The study's purpose is to provide a detailed analysis of current and upcoming diagnostic tools, as well as speculate on future strategies. We searched the Cochrane database for systematic reviews and meta-analyses, as well as the most recent international recommendations, to get a fresh look at PCOS.</p> Mudasir Maqbool, Irfat Ara, Imran Gani Copyright (c) 2022 Mudasir Maqbool, Irfat Ara, Imran Gani Mon, 28 Nov 2022 00:00:00 +0000