Alteration of Coagulation Profiles in Hypothyroid Patients


  • Khalid Abdelsamea Mohamedahmed Department of Hematology, Faculty of Medical Laboratory Sciences, University of Gezira, Wad Medani, Sudan
  • Ahmed Hassan Ahmed Department of Immunology, Faculty of Medical Laboratory Sciences, University of Gezira, Wad Medani, Sudan
  • Albadawi Abdebagi Talha Department of Clinical Laboratory Sciences, Jouf University, Saudi Arabia
  • Asaad Babker Department of Medical Laboratory Sciences, College of Health Sciences, Gulf Medical University, Ajman, UAE


Prothrombin time, INR, Hypothyroidism, Sudan, PTT, International normalised ratio



Hypothyroidism is an underactive thyroid gland that results in too little thyroid hormones in circulation causing a slowdown in metabolism, therefor hypothyroid modifies physiological process of primary and secondary hemostasis and may lead to a higher bleeding risk.

Objectives: The aim of this study is to assess the coagulation profiles [Prothrombin Time (PT), International Normalize Ratio (INR), Activated Partial Thromboplastin Time (PTT)] in patients with hypothyroidism.

Methodology: This is a case-control hospital-based study carried out at the National Cancer Institute – University of Gezira (NCI-UG), Wad Medani, Sudan from January to October 2020. A total of 100 (50 patients with hypothyroidism as cases (38.50 ± 10.46 years) matched with 50 normal healthy individuals as controls (35.52 ± 11.64 years) participated in this study. Two ml of venous blood sample was collected in a trisodium citrate container. Coagulation profiles (PT, INR, and PTT) were measured using a Coatron M4 coagulometer. SPSS computer program (v 21.0) was used for data analysis.

Results: The prolonged PTT account for 74%. The average PTT of cases (42.29 ± 7.22 sec) was higher than controls (32.67 ± 5.90 sec) giving highly statistically significant differences (P value = 0.000) between them. There were significant differences in PTT between mild and severe hypothyroidism (P value = 0.0470). PTT had significant positive correlation within TSH (P value = 0.048; r = 0.070) and significant negative correlation within T3 (P value = 0.000; r = - 0.490) and T4 (P value = 0.020; r = - 520; P value = 000).

Conclusion: The study concluded that PTT was significantly higher in a patient with hypothyroidism when compared to the control. PTT results showed there was a significant negative correlation between T3 and T4 levels and a significant positive correlation with TSH levels. So, PTT should be included as a follow-up routine test for patients with hypothyroidism.

Keywords: Prothrombin time, International Normalized Ratio, Partial Thromboplastin Time, Hypothyroidism, Sudan.




How to Cite

Mohamedahmed, K. A. ., Ahmed, A. H. ., Talha, A. A. ., & Babker, A. (2022). Alteration of Coagulation Profiles in Hypothyroid Patients. International Journal of Current Research in Physiology and Pharmacology, 6(2), 1–5. Retrieved from



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